Procalcitonin versus creactive protein in neonatal sepsis ali am1, elkhatib wf2,3 and abdelaziz ss4 1department of pediatrics, faculty of medicine. Septic shock is defined as a subset of sepsis, with the requirement of vasopressor therapy to sustain a mean arterial pressure of. Neonatal sepsis is a clinical syndrome of systemic illness accompanied by bacteremia occurring in the first month of life. A differential diagnosis of infection caused by either bacteria or other microbial organisms is essential for effective treatment and prognostic assessment. Jan 15, 2016 septic shock is defined as a subset of sepsis, with the requirement of vasopressor therapy to sustain a mean arterial pressure of. In these studies, pct sensitivity in the early diagnosis of neonatal sepsis was found to be 83100% while the specificity was 70100% 9, 12, 18.
Procalcitonin in detecting neonatal nosocomial sepsis. Prompt diagnosis and treatment of neonatal earlyonset sepsis are crucial to prevent severe morbidity and mortality. Accuracy of serum procalcitonin for the diagnosis of. However, as an expression of individually different immune responses and different clinical situations, the same focus of infection may be associated with varying individual elevations in pct concentrations. Y zahedpasha, et al previous studies had shown high pct levels in all neonates with proven or clinically diagnosed various types of neonatal sepsis8,2,22,24,25. Proven earlyonset sepsis has mortality rates as high as 30% in highincome countries and up to 60% in lowincome countries ref5, 6. Procalcitonin shows a physiological elevation in newborns right after birth ref7, 8, therefore, to use pct in neonates during their first 4872 hours of life, agespecific pct reference values apply. Abstract sepsis and its implications remain a constant challenge for the physician. The overall incidence of primary sepsis is 15 live births. Neonatal sepsis is one of the leading causes of death as reported. Feb 05, 2011 many authors found that procalcitonin is a promising marker for the diagnosis of neonatal sepsis 10, 12, 18. But some investigators questioned the diagnostic accuracy of pct in detecting of.
Procalcitonin pct was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Uti is discovered as part of an evaluation for neonatal sepsis 1. These findings support the usefulness of the pct to establish an early diagnosis of neonatal sepsis. Neonatal sepsis is a leading cause of global mortality in children younger than 5 years ref4. Sepsis, sepsis neonatal, procalcitonina, marcadores, sensibilidad, especificidad. Research article open access procalcitonin versus c. Sepsis is the systemic response to infection by microbial organisms. Many authors found that procalcitonin is a promising marker for the diagnosis of neonatal sepsis 10, 12, 18. Reference values in sepsis brahms pct procalcitonin. Apr 24, 2017 a number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified.
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